| Identifikační kód |
RIV/68081707:_____/18:00502727 |
| Název v anglickém jazyce |
Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents |
| Druh |
J - Recenzovaný odborný článek (Jimp, Jsc a Jost) |
| Poddruh |
J/A - Článek v odborném periodiku je obsažen v databázi Web of Science společností Thomson Reuters s příznakem „Article“, „Review“ nebo „Letter“ (Jimp) |
| Jazyk |
eng - angličtina |
| Vědní obor |
10402 - Inorganic and nuclear chemistry |
| Rok uplatnění |
2018 |
| Kód důvěrnosti údajů |
S - Úplné a pravdivé údaje o výsledku nepodléhající ochraně podle zvláštních právních předpisů. |
| Počet výskytů výsledku |
2 |
| Počet tvůrců celkem |
2 |
| Počet domácích tvůrců |
2 |
| Výčet všech uvedených jednotlivých tvůrců |
Viktor Brabec (státní příslušnost: CZ - Česká republika, domácí tvůrce: A, vedidk: 7988346, researcherid: C-1075-2013)
Jana Kašpárková (státní příslušnost: CZ - Česká republika, domácí tvůrce: A, vedidk: 4571932, researcherid: H-1951-2014) |
| Popis výsledku v anglickém jazyce |
Ruthenium complexes exhibit a broad variety of biological and biomedical activities including anticancer efficiency. The reason is that the octahedral bonding of both Ru(II) and Ru(III) complexes affords an extensive repertoire of three-dimensional architectures, giving the potential for a high degree of site selectivity for binding to their biological targets. The mechanism of biological and biomedical action of ruthenium compounds is connected with their interactions with biomacromolecules. A lot of mechanistic studies revealed disposition of many ruthenium complexes to operate via mechanisms of action involving interactions with DNA, but distinctly different from those of the approved platinum anticancer drugs. In this Review, we discuss major DNA binding modes hitherto identified for ruthenium complexes of biological or biomedical significance and provide some typical examples. The introduction provides the reader with a brief overview of the approaches in the search for the new, transition metal-based agents of biological or biomedical significance to provide the context in which more recent research of DNA binding of ruthenium complexes has been evolved. We then describe main categories of binding modes between DNA and ruthenium compounds, such as coordinative, intercalative, minor groove binding, sequence specificity of DNA binding, the ability of ruthenium compounds to condense and cleave DNA, binding to A- and Z-DNA, DNA quadruplexes and other unusual DNA structures. A number of complexes based on ruthenium(II) centers have been reported to have excellent photophysical and radiosensitizing properties so that DNA photocleavage and synergistic enhancement of DNA damage due to a combined action of ruthenium complexes and ionizing radiation is also discussed. Finally, inhibition of DNA processing enzymes is reviewed as well. We believe that such a synthesis of disparate DNA binding modes of ruthenium complexes will help to generate new ruthenium complexes of improved biological and biomedical significance. (C) 2018 Elsevier B.V. All rights reserved. |
| Klíčová slova oddělená středníkem |
cell-free media;arene anticancer complex;g-quadruplex dna;ii polypyridyl complexes |
| Stránka www, na které se nachází výsledek |
- |
| DOI výsledku |
10.1016/j.ccr.2018.07.012 |
| Odkaz na údaje z výzkumu |
- |